I have a perhaps unusual opinion of Janeway; I thought the character was by far at her most interesting on occasions like Tuvix when she made a potentially morally questionable call, but stuck to it with all the force she could, damn the subtlety. It was a character beat most of the other captains, Picard especially, didn't really have.
My personal favorite, I forget the episode title, was the one where aliens were abducting people into holodeck recreations and stealing their ships. Janeway basically ruined their entire method of sustaining themselves because they pissed her off; I loved it.
I contend that Endgame is different though. That wasn't a questionable moral stand - it wasn't a moral stand at all. It was entirely selfish.