gturner wrote:

[...]For such people, losing weight through the normal mechanisms (which are based on having a working cross-feed system) would be like trying to shrink a tumor by exercising, on the theory that it will eventually burn off.
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These persons make up only a small percentage of the overweight ones.
Proof is the percentage of the overall population that was overweight in 1900 (or 1950, 60...) by comparison to the percentage of the overall population overweight now.