Nah, I'd rather see Captain Deanna Troi commanding the Titan by the 2390s (and Beverly getting her Pasteur).
This made me a little ill just thinking about it.
Any ship is there to serve the story. If they decide they want to move Riker and Troi back to the Enterprise with a bang, destroying Titan would accomplish that purpose. Or we could see the Enterprise destroyed and a Vesta-class namesake introduced. Or nothing at all could happen...
But something with a dramatic name like The Fall
, I hope it concentrates on the Federation. Not an alliance that never seemed like an alliance to begin with.