Or, how about a Trek trapped in the future--the Federation has fallen, and the ship is weaker (to a significant, but not crippling, degree) than whatever race/federation/etc. is currently running things.
Sounds a shade like Andromeda
There have been claims, true or not I've no idea, that Robert Hewitt Wolfe initially pitched a new Star Trek series, in which a single Fleet ship is somehow sent forward in time and struggles to rebuild the collapsed Federation. This concept was allegedly turned down by the executive producers, who disliked the idea of the Federation falling.
Wolfe later developed the core idea into Andromeda
, incorporating some ideas (and the name Dylan Hunt) from a couple of Gene Roddenberry's projects, Earth II
. As such the series was known as Gene Roddenberry's Andromeda,
even though he had no personal involvement in the series.