I could have sworn in DS9, 'Bolias' is referred to in the same breath as other core planets of the Federation. After the Dominion conquered Betazed, didn't they say 'This puts them in striking distance of Bolias'? Or was that also Berengaria?
If a first year medical student would ask the question 'Have you recently had sex with a bolian', doesn't that imply it's a common problem to do so? If they're not members of the Federation, they're clearly firmly within Federation space and very friendly with the Federation.