well, one of my best friends is transgendered. I knew her as a man for a decade or longer then as a woman. My husband has been friends since he was 8. I can see a
resemblence but I don't think it's the same thing.
As was proved later in DS9 in a court, a trill is not the same person they were in previous joinings because they are two personalities and lives joined.
a transgendered person is still the same person. The packaging is just a little different. And the pronouns. Belive me, the pronouns are the biggest issue for other people. lol