There is nothing in-universe stopping him from returning. However, whether the film PTB (Abrams, for now) and Nimoy would ever be onboard together for Nimoy's return to the film is doubtful in my opinion. But, yeah -- books and comics? Why not?
Although, who knows? -- Maybe in 40 years, Zach Quinto will agree to play Spock prime opposite some yet-to-be-born young actor playing Spock in some future re-boot of the film series.