Use cheaper paper and less colors, high quality glossy paper is a waste of money, it is more expensive and adds barely nothing to the experience.
Get rid of the shared universe! All heroes should exist in their own worlds, no crossovers etc., Superman doesn't exist in Batman's world. You can still have a Justice League, but it wouldn't be in continuity with the other books.
Don't have several books featuring the same character or members of the same group, no Batman/Detective Comics/Nightwing/Red Robin/Batwoman situation. There's only one book that tells the story of this world.
Introduce a company style that the artists are forced to use! No individual styles, every character should look the same no matter who draws him/her, screw the artsy stuff. You want to draw in your own style? Create your own stuff at your own company.
Do a hard reboot, ditch everything, even the successful stuff, start over and don't look back.
Fire long time writers and perceived stars of the industry like Morrison et al., get new blood and new ideas and as soon as someone declares himself a fan of character A make sure he doesn't write character A.
Adopt the writer's room that tv shows have, hire 4 or 5 writers for one book, let them work together, throw around ideas, plan the storyline and then write individual issues with a head writer overseeing them.
The monthly books should have at least 50-75 pages, it's not hard to do if several writers and artists work together.
The most important part: Make the books accessible! That's why getting rid of the shared universe and not having several book for the same character is important. Don't make readers feel like they need to read other books to get the full experience and don't crap on your writer's stories by forcing a stupid event on them every summer.
Do another hard reboot after five years, allow your current version of Spider-Man to end. Let him die (for real) or let him live happily ever after, let him go to prison after he snapped and murderd Norman Osborn or let him be celebrated as a hero after he proved himself to everyone. Having a set time before the next reboot allows for more interesting stories and it allows to have lasting consequences, you can kill characters off without retconning the shit out of the story 3 years later to bring them back, just wait until the next reboot.