If they were sheep they were sheep the way Khan's followers were sheep, in that they obviously desired a leader and fell into a hierarchical social structure. The generation of eugenics ENT and Space Seed augments came out of may have included a tweaking element of that, after all if you're going to rule the world you cannot all want to lead. There is no comparison to Jack's Pack other than that eugenics were involved.
The hundreds of years is completely relevant, the purpose for the eugenics as well as what they actually were doing was a very different thing.