I would've liked to see Voyager return home at the end of Season 6 and then use Season 7 to explore the crew adjusting to life back in the Federation. That would provide a lot of opportunity to also explore the post-Dominion War landscape and maybe allow for some TNG and DS9 crossovers as well.
Perhaps a threat from the Delta Quadrant could've brought the crew back together for the series finale. There was the Voth, Species 8472, Vaadwaur, and of course the Borg. Voyager wasn't lacking in big adversaries.
Absent that, I wouldn't have minded if they never made it home during the course of the series, making the ship home instead.