A is for Art. Commander Data enjoyed painting during his time aboard the Enterprises-D and -E.
B is for Beagle. Captain Archer enjoyed playing with his Beagle, Porthos, in his spare time. Just don't feed him any cheese.
C is for Cardassians. They spent much of the 24th century in direct or indirect conflict with the Federation and other powers.
D is for Dominion, the rulers of the Gamma Quadrant.
E is for Eggs. Will Riker kinda sucked at cooking them into an omelette.
F is for Fencing. Guinan and Picard shared a few matches on the holodeck.
G is for Gowron. Chancellor of the Klingon High Council for almost a decade.
H is for Heisenberg compensators. Vital component of the transporter system.
I is for Io. A moon of Jupiter. One of the first NX warp tests in the 2140s catastrophically failed near Io.