I reckon he'd try and turn it into a Dr. Phil style show.
"I have the wisdom and experiences of two men!"
He'd have a very hard time finding guests. Maybe he'd book the Delaney sisters and try and shmooze them about how he really understands twins because he's two people too. He'd say a lot of inappropriate things thinking he was being charming. It would be a fabulous train wreck but since Starfleet doesn't do that kind of humor, a short lived one.