I wonder what the show would have looked like if they kept to the concept of wagon train to the stars? For one there was very little settlement in Star Trek, the show was about explorers not settlers. If it was to keep true to the wagon train concept...
This is a common enough misconception. When Roddenberry used Wagon Train
as shorthand he wasn't referring to the format i.e. settlers traveling west. What he was referencing was the idea that the series wasn't set in one place, and that, like a wagon train with its many wagons and members of the party, the ship was big enough to have lots of people pop up for an episode, tell a story about them, and they could disappear again. Likewise, just as the wagon train could meet people along the route, his starship could meet people on various planets and on other ships it encountered.