What did Amy do after her time with the Doctor? She became a model and nearly divorced her husband.
I'm not sure it's dramatically different from Donna. Sure, with the "nearly divorced her husband" part, it's bad, but, otherwise, she had a successful career where she could make a decent amount of money. Every person with the Doctor is different. I guess Amy's big thing is just having a life separate from the Doctor because he was always with her since she was a little kid.