A CSI Trek wouldn't work, the level of technology makes it pretty redundant.
no, csi like trek uses technology, but it's the people on csi, the ones doing the investigations, the victims, and the criminals, that are the story, not the technology.
a star trek "csi' would not have to be a crime show, the point is a team investigating a mystery, procuring pieces of knowledge, each member providing a puzzle piece, putting them together in front of the audience each week, and ending the episode with a successful result (or sometimes unsuccessful one).
the original csi and it's spin offs combined have 30 seasons and 700 episodes, there's an old saying bry sinclair, give the audience what they want.
again, it wouldn't have to be about crime.