I'd like to see something that actually moves away from the standard ship & crew format we've seen for five series and eleven movies. They've got a whole universe to work with, but most people seem to want different variations of the same standard formula.
And nothing like a Trek Law and Order, or Trek CSI. Come up with something more original than doing another genre within the Trek universe.
You seem to contradict yourself, asking for a very rehashed genre/format but in a Trek style.
A CSI Trek wouldn't work, the level of technology makes it pretty redundant.
A non-standard Trek would really need to be original in its approach and execution. So long as they had good characters and stories, it really could be set anywhere. But they need to repair the damage done by VOY and ENT and get viewers back to Trek.