I just think the way the Prime Directive is used in the 24th century is wrong. You invade a species territory and infiltrate their society without asking then you refuse to help when they face an extinction level crisis.
When you get into that close of a relationship with another species, I think you take on certain obligations. You take on the obligation not to interfere but at the same time I think you take on an obligation to protect them from things they may not understand as threats to their species as a whole. The Federation is extracting reams of knowledge yet offers nothing in return to these fledgling species.