The one issue I just thought of is with communication. Would you have to stop to make a transmission?
For most of human history, exploring, trading and even patrolling military ships were out of contact for months at a time while at sea and the fastest way to send a message anywhere was to hand it over to a ship heading in that direction.
It would be risky, but it wouldn't be an unprecedented feet for explorers to be out of touch. We send a ship to Alpha Centauri, we hear of their year long exploits in the system when they come home two years later.
In other news, my wife usually keeps a few kilograms of exotic matter in the back of the fridge, which I would be willing to donate to the cause.