As for the size of the Federation: Daniels' line leaves a lot of room. There are, AFAIK, about 150 members of the Federation in TOS' time. Four hundred years after that, I'm sure there could be a lot more. If the Federation jumped to over 900 members by that time, it would still fit with what Daniels said. Daniels said "hundreds", but even if taken literally, any upper bound that establishes will still allow the Federation to grow, grow, and keep growing.