Mars wrote:

One can for instance predict the weather without simulating the path of every molecule and atom in our atmosphere ... The human brain can be simulated in similar detail.
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Ah, so it can be simulated to a rough degree of accuracy, but no better? And you can guess what it will do some of the time, and other times it will behave totally freakishly and unpredictably?
Not a human being I'd want to hang around with. Keep it away from sharp implements.