I have played several STFs in my Regent class USS Eaves (Named after John Eaves, the person who designed the Sovereign). So far the only time I've been killed is when I had to simultaneously tank the Cube, Negh'var and Raptor for a long time as no one else was attacking them.
I think that's pretty good for a ship with a single hull heal. Here's my BOFF layout:
Tac #1: TT I, FaW II
Tac #2: FaW I, APB I, TS III
Tac #3: TT I
Eng #1: EP2W I, DEM I, EP2S III, A2SIF III
Eng #2: EP2S I, RSP I