I can't believe I forgot Tyrion Lannister from Game of Thrones (or that no one else has mentioned him). I wasn't sure for a while if little people were considered disabled, but there have been several little person swimmers at the Paralympics, so they are.
And of course Vader and the Alphas characters would go on my list too. I forgot about the fact that they have had so many people on Alphas who's powers' disadvantage lead to a disability.
Ok, I know I said favorites, but I think we can just open up to a discussion of the topic in general, without picking just our favorite characters.
I also just remembered pre-timeline change Kevin from Eureka.