Miles Vorkosigan from the Vorkosigan novels has a host of medical difficulties, including extremely brittle bones (requiring surgery for replacements to be able to walk) and in later life suffered from quasi-epileptic shock. It'd be fair to say that medical themes in particular are a recurring idea in those books, and his physical issues are a constant.
Joker in the Mass Effect series of games also had brittle bones.
If being stupid counts as a disability then I would have to mention Philip J Fry
Since he's so abnormally stupid he doesn't have brainwaves that most all human and animal life and some plants possess... yeah, he may arguably count.