I'm sure there will be a past Whedon show actor as one of the regulars on this. Possibly more than one... There will definitely be guest star appearances as well.
I think the show could also be a good platform to then 'spin-off' into other areas. We've heard Cloak & Dagger and Mockingbird be mentioned as possibilities for shows in the past. You could easily see them worked into this show. I could even see ABC do something like you had them appear for a few episodes in SHIELD and then ABC-FAMILY would premier that character's show as a summer series.