Re: Joss Whedon's S.H.I.E.L.D to ABC!
I think it's almost certain that there will be somebody with superpowers in the main cast. This is a Marvel show, even if it's focused less on the superheroes themselves. We'll also probably see superheroes and villains turn up in guest spots pretty regularly, I would think.
"In blackest day, in brightest night, beware your fears made into light. Let those who try to stop what's right, burn like my power: Sinestro's might!"