The show itself can work week in/week out under various genres. I'm more interested in what characters will be used and actors cast. Will we have comic characters used to head up SHIELD or will they go the Coulson route again and try to create a character. The latter would allow for some flexibility in drama I'd think.
Now I wonder if they will try to have this as a mid-season debuting show around Jan '13 before Phase 2 of MCU starts or a Fall '13 show after IM 3 has opened? Depending on what, if any ties to the MCU, would there be a benefit?