I'd love a new Trek series with a non-human character in the lead role (that doesn't mean make them a hologram, android, or anything like that). I often find the alien characters more interesting anyways.
Well what can you do besides have forehead ridges or pointed ears? Spock commanded the Enterprise on a number of occasions.
Huh? There's plenty that can be done. Just take a look back at the movie and show Alien Nation
. One main character is human, the other main is alien. You actually get the perspectives of both AND learn about how similar or different "George Fransisco's" family and species are in contrast to humans. Another example - Delenn from Babylon 5 is (arguably) a main character in Season 1, and during this time, we get her alien
perspective on events which take place.
The concept of an alien captain can certainly go wrong, but only if the writers follow your assumption that they are just humans in weird make up...
Centurion: "...power is danger."
Romulan Commander: "Danger and I are old companions." - TOS episode Balance of Terror
"Living in your dreams is like living in exile." - Calyx, A Stitch in Time
"Shame on you, Barack Obama!" - Hillary Clinton
"It's the economy, stupid." - Bill Clinton