I have that, but I've put off reading it because I've never read the two Star Trek/X-Men comic books. Does the novel acknowledge them, or is it a totally separate take?
is loosely a direct sequel to the TNG/X-Men crossover Second Contact
, in that it features the same team of X-Men having a second encounter with the E-E crew, although for the X-Men it's immediately after the end of the comic while for the TNG cast it's a year or two later. Still, the specifics of the comic's story don't come into play; all you need to know is that these particular X-Men have met Picard and crew once before. Which is no worse than, say, "Coming of Age" establishing that Picard and Admiral Quinn knew each other before. You don't need to have seen their earlier meeting to follow this new story.