I think the genetic engineering reveal actually ties up a couple of strings of Bashir's character. He missed a simple question on his final exam and lost out on being valedictorian. He could have been a tennis pro but never made it. To me, it makes those earlier episodes even more interesting after learning his secret.
Well, I'm going from memory here, but... doesn't the genetic engineering change the motivations for all of that? He's really smarter than everybody, has better hand/eye coordination, etc., but is trying to "blend in"?