I don't see how they could go together. Firefly/Serenity
is devoid of FTL travel or alien life, and Dune
has both. The only points of similarity I see offhand are that there are psychic powers in both (a common trait of many SF universes) and that Earth has been destroyed in the Dune
universe -- except that happened around 12,800 CE, whereas FF/S established that "Earth was used up" centuries before the series' timeframe of 2517 CE.