I like the 2380's setting. It would be cool to focus on the Federation possibly developing a friendship with the Romulans and assisting their rebuilding efforts with CDR Donatra. This could be a great segue for the Klingons to become what they were truly meant to be. BAD GUYS!
The Klingons have been allies but they seem to get kind of ancy in peace time. They could have it so that they slowly start to get annoyed by our aid and assistance to the Romulans. A few skirmishes here and there. I'm not saying I want another war story that enveloped the last few seasons of DS9 but I did enjoy the matching of wits with Kirk and those classic Klingon confrontations in TOS.