^A nice theory, but I don't suspect it'd work well in practice. 1 in 4 American women have been sexually assaulted. If you're a comedian in a 50 seater room, of which half the audience are women, statistically you could expect at least 5 or 6 of your audience members to have been sexually assaulted in the past (and that's not including the men). So how exactly does one operate by a know your audience rule?
Anyway, I don't think Tosh is being ripped apart for making rape jokes. He's being ripped apart because after being heckled about his rape jokes he made a shitty comment about the heckler which he tried to pass off as a rape joke. Sorry, but saying that it'd be funny if a woman were gang raped in the club then and there just isn't funny. Again, I'd suggest reading this article, How To Make a Rape Joke
. The author explains the issues very well.