It just wasn't ever really credible that they they're organized enough for spacefaring, but then you have the Pakled ...
There's an idea- a Pakled crew member on Titan. But then, how about a Horta
You can have a Pakled captain in STO. I wonder if anyone has actually chosen that option?
That is about as crazy as a Mugato in starfleet...hmm, wait a minute...
I'd Like to see the Vidiians revisited in the Voyager series. I'd like to see what became of them after the 'Think Tank' reference. They were like bizarro Borg... 'Your biological likeness will adapt to service us so that we don't melt into goo'