Well, this is what I think
Star Trek is a story about exploration. in TOS Era, we have already have exploring Alpha and Beta Quardrant while in TNG, Voyager, and DS9 we have Gamma dan Delta.
So..., if Star Trek wants to keep it's genre without having repetitive like the previous story. They must aim another galaxy with different concept. It will funny if we have a 25th century Star Trek with similar 24th Century Star Trek plot and story. Why should repeat the old one if we can refresh them to new Star Trek?
So rather than we retold Federation conflict against Klingon, Romulan, Borg, and Dominion, why won't we create a new stage for the next series?
Vulcan, Klingon and Romulan were spectacular idea for old Star Treks. But if we just represent them again and again, there will no novelty in Star Trek anymore.
So... rather than telling the same story with different casts and ships, we should do 2 things :
1. Reboot Star Trek and create a new universe with 100% different species inside it (no Vulcan, Romulan, Klingon, etc)
2. Use different galaxy as the stage. We can say that Enterprise is a moveable Star Base / mega Star ship like carrier that can be docked by other smaller ships. The main hero will Admiral and not a mere captain, and because it is in a different galaxy, we won't find Federation, Klingon, Romulan, etc anymore (beside the Enterprise crews).
With this new settings, Star Trek can goes and explore new plot or story that free from their previous series. Thus give us new / fresh Star Trek with the same exploration theme and USS Enterprise.