Yep, that's what they said -- that all the villains will be characters never before portrayed in animation, ranging from recently-created, modern villains like Pyg and Toad all the way back to obscure baddies who appeared once or twice in the Golden Age.
Although I'm still not convinced they'll maintain that practice throughout the entire series. I suspect that after a year or two, once they've given this show time to establish its own voice and identity, they may bring in some of the familiar foes.