One example would be asking for help in a war that had nothing to do with the Feds.
The Cold War could have easily ended in the extinction of humankind. So make up your mind, is preventing extinction only OK in the case of natural catastrophes and not in the case of cultural ones or what and why the distinction between cultural and natural and what about the cases where you cannot make a distinction between them?
I am just looking for some consistency. On the one hand people are saying that human ethics should be universally applied in the galaxy but then they do not like the word dogma and want the Prime Directive to be a very lax rule. Seems like Swiss Cheese not me and not like a thought-out position.