A is for Aging. As in premature, which the Third World War and frequent alcohol consumption led him to.
B is for Booze. He was a big fan.
C is for Contact, he was the first to have it with Vulcans.
D is for Delta Quadrant, where the aliens that attempted to stop him came from.
E is for Everything. As in: "What does Zefram Cochrane drink?"
F is for Federation, the foundations of which were laid by first contact.