What's wrong with her now?
The roll should be cast with several appearances if not a solo outing on the horizon.
At 40 that limits her, it's just a Hollywood fact.
The rules for men/women aren't always the same.
It's why RDJ works but she wouldn't.
No one is casting mid 40yr old men to play Bond for the first time.
I'm strictly speaking on it from an industry viewpoint.