An interesting question KingDaniel. I agree that Michael Dorn's movie is probably a long-shot, but if it does happen and is thus declared canon, I'd like to think that all of the current storylines would be wrapped up and then a new separate era with the new status quo would begin.
Failing that, you could have some huge galaxy-wide crisis which results in the giant reset button being hit. This will likely be the preferred route, go out with a bang, not a whimper.
Currently reading: Typhon Pact: Paths of Disharmony by Dayton Ward
Next up: The Fall: A Ceremony of Losses by David Mack