But like I said, the overriding survival need for House isn't money or comfort (though those help), but problems to solve. Like Holmes, he's only content when his mind is engaged with a fascinating and intractable problem.
I think they should do a spinoff. "From the people who brought you House M.D. -- it's House, P.I.!" He could move to Hawaii and get an acerbic butler.
I'm in agreement with Chris. House needs a mystery to solve, that's what drives him, takes his mind off his leg, gives meaning to his life.
Suicide might be one answer. I remember Sherlock Holmes once said to Watson in 'The Sign of Four', to paraphrase, if you're not doing what you're good at then there is not much point in living.