^I would freaking LOVE Mysterio. I don't see it happening though
. I could see Spidey becoming mainstream and getting a movie deal, but somehow he causes a special effects man to lose his job
In principle I don't want rehashed villains (I also think Electro would work really well on the big screen, visually at least), but Green Goblin is the major one, and Oscorp is in this film. Seeing as this is a 'darker' take Venom could be done justice. Unlike most I quite like Spider-Man 3, but it was a bit unfocused.
I would have loved to see a film with Kraven in the mix as well as The Lizard (not as an origin story though).