Nah, they're better off making it a wholly CGI cartoon along the lines of the Green Lantern show that's on or the upcoming Cyborg 009 reboot/adaptation. Considering how some of the designs in the 2D ME anime turned out, going all CGI would be a good way to maintain consistency with the look established in the games.
The only problems are figuring out who'd want to do this now
, in the aftermath of the ME3 ending, and figuring out a way to ensure that whoever ended up broadcasting it would actually advertise the damn thing. Cartoon Network has a bad habit of not advertising shows they air for some retarded reason.