As I've said before, there are certain realities of TV production that are going to require significant deviations from what I understand to be the comic book storyline.
One is that Carl is going to have be recast, written out or the entire show subject to a time jump.
Another is that, given the budget constraints on the show as is. For example, I doubt the producers are going to want to go the time and expense of having a lead character played by
spend the rest of the series
, though I could be wrong.