Interesting idea. I wouldn't have thought to do a crossover like this, even though I have in the past attempted to meld the concept, storylines, and characters of B5 with Star Trek, albeit in the form of trying to adapt them to the Trek 'verse rather than the other way around (sending Trek characters into the B5 'verse), and I'm interested in seeing where you take things.
I'd also be interested in seeing a crew manifest for your version of the Aventine, since there seems to be a lot of new crewmembers who weren't mentioned in the Destiny novels and their follow-ups.