I listen to mostly sports podcasts, but the non-sports ones I listen to:
BS Report with Bill Simmons (It's mostly sports, but this last week he had a great interview with Louis CK)
NPR's Pop Culture Happy Hour
NPR's Car Talk
NPR's Wait Wait...Don't Tell Me!
Slice of Scifi (Even though I'm getting a little tired of it and some of the dorky segments they've been having)
a TV podcast with Tim Goodman, former critic of the SF Chronicle
A Podcast dedicated to Glee
In terms of Sports, it's a whole lot more:
The Backhand Shelf (Hockey Podcast with Rob Pizzo and Justin Bourne)
A 8 minute daily conversation with John Maddan.
A SJ Sharks Podcast called Dudes on Hockey
ESPN: Baseball Today
ESPN: Fantasy Focus Football (And Baseball)
ESPN: Football Today
Marek vs. Wyshynski (Hockey, but more obscure Hockey, Podcast)
Puck Podcast (Weekly Hockey Podcast)
I love podcasts. It's much better than the repetitive and boring style of radio.