I'd like to see Quantum at least referenced in the next film, but I don't think it needs to go overboard on it. Maybe have Bond infiltrate their operations for the pre-title sequence or something?
As for Skyfall? Interesting, and like Lonemagpie says, could imply a variety of things, even a person!
Ah, Mr Skyfall I presume!
Plus creating it specifically for the film means it its seamlessly, rather than being shoehorned in like Quantum.