One of the things I'm curious about is that the Mikes said Supergirl would have a supporting cast. I sort of think that's a mistake, but nothing to be done about it; you need people for the talking.
Since she doesn't know anything about humans that could be darkly funny.
Supporting characters: "Please we don't live in cages!"
Supergirl: "what sort of owner would I be if I let you monkeys wander around uncared for?"
Or maybe an issue where Superman had to explain to a baffled Supergirl why eating human flesh is prohibited.
Sadly I doubt they will go that way....
"I find the one moon to be displeasing, and I shall correct it. The planets you call 'Mars' and 'Mercury' aren't doing much, are they?"
Supergirl: Fucks up the World
would be a fun comic. Limited potential, but I'd buy it.
P.S.: upon review even Byrne drew Lara with lipstick (tasteful, not too flashy, but still).