I'd love to see a Doc Strange movie done well. He's always been one of my faves.
As for the actor, how about that guy who played Baltar on nuBSG and Doctor Old Spice on Eureka?
You mean James Callis? He isn't conventionally handsome enough to play a lead superhero. But a villain or second banana would be perfect for him, assuming he's high profile enough to be considered for such a role, which he probably isn't.
Superheroes need to be conventionally handsome like Chris Evans, or if they're somewhat off-kilter characters, they can be unconventionally handsome like Robert Downey Jr. But the acceptable range is very narrow. The likes of Jeff Goldblum are entirely off the menu.