I'd like to see a mix-and-match of the 'fresh start' and 'returning crew'
Captain Ro Laren - okay, cool. I like this.
First Officer - Sam Lavelle? Maybe even play with some of the material from the TNG DW books involving him an Ro. Or even better - Thomas Riker!
CMO - Bashir, of course.
Security Chief - Lt. Commander Nog, returned from the Challenger. Quark would still be around, and it would be a fun counterpoint to have Nog filling Odo's shoes.
Ops - Chief O'Brien finally returns.
Sciences - Mixed. I'm not sure if I want Shar back, or someone new. Leaning towards someone new.
After that, a couple other new characters to fill things out wouldn't be bad. Aventine could come by for missions periodically, as could the Robinson, depending on how that story goes.