Nick The Munificent wrote:

It's not obvious to me at all. He has no problems communicating .. it's what he communicates which interests me.
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^He very, very likely has symptoms of Asperger's Syndrome - which is a high-functioning form of autism:
http://www.ninds.nih.gov/disorders/a...l_asperger.htm
(I have meet quite a few people in the science community with some form of Aspergers.)
In fact, Sheldon's character has become very popular with parents of kids with Aspergers - and TBBT has been refereed to by Slate magazine "the first autism sitcom".
Slate: Is the World Ready for an Autism Sitcom? <
http://www.slate.com/id/2210635/ >
http://myfavoriteatistic.blogspot.co...ng-theory.html
Autism Goes Prime Time: The Big Bang Theory: <
http://open.salon.com/blog/libertari...ig_bang_theory >
Psychology Today article on Sheldon and Aspergers:
http://www.psychologytoday.com/blog/...ig-bang-theory
The Autistic Journalist blog article on Sheldon:
http://www.psychologytoday.com/blog/...ig-bang-theory
The Big Bang Theory & Sheldon discussion on an autism discussion board:
http://www.wrongplanet.net/postt81946.htm
^Just to name a few...just Google "The Big Bang Theory Sheldon autism Aspergers" and the list of links about the connections are pretty long...
Sheldon also pretty obviously has OCD - Obsessive Compulsive Disorder (I know, I have it myself) but like autism and Aspergers, "OCD" is never mentioned on the show by name...